"Alterations in axonal membrane and channel function occur early in the disease course, prior to discernable large fibre involvement, and has the potential to be used as an early biomarker of ...

This is a preview. Log in through your library . Abstract βII-spectrin is the generally expressed member of the β-spectrin family of elongated polypeptides that form micrometer-scale networks ...

Axonal and dendritic proteins embedded in the membrane at either end -- called transmembrane proteins -- are built in the same cellular factory and travel on the same cellular highway. But for the ...

In Alzheimer’s, and in mouse models of the disease, axon membranes bleb up in the vicinity of amyloid plaques. What if there was a way to prevent these dystrophic neurites from forming? As reported in ...

Biology textbooks may need a revision, say Johns Hopkins Medicine scientists, who present new evidence that an armlike structure of mammalian brain cells may be a different shape than scientists have ...

Recent studies have shown that under the axonal membrane, rings composed of actin filaments give the structure its flexibility. But those studies had not been able to define the precise architecture ...

Biology textbooks may need a revision, say Johns Hopkins Medicine scientists, who present new evidence that an armlike structure of mammalian brain cells may be a different shape than scientists have ...

Axons are the brain’s information highways, transporting cellular cargo, chemical signals, and electrical impulses to other cells. These “roads” are typically depicted as smooth and cylindrical, with ...