Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain ...

Aging cells secrete substances known to promote the growth of cancer cells. The development of drugs that can selectively kill these cells or inhibit the secretion of substances is ongoing. The latest ...

Mount Sinai and BPGbio scientists uncover novel molecular drivers from live brain samples that direct human brain structure and function from ...

This illustration shows the major cell types affected by cellular senescence in various skeletal diseases. As the body ages, senescent cells accumulate in different tissues—including bone, cartilage, ...

Knowing which lysosomal proteins are enriched in which brain cell types will help better understand contribution to neurological disorders.

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and ...

Senescent skin cells, often referred to as zombie cells because they have outlived their usefulness without ever quite dying, have existed in the human body as a seeming paradox, causing inflammation ...