A peptide bridge is designed to construct a fusion enzyme with electrostatic cofactor channeling, reducing NADPH input by two orders of magnitude or decreasing reaction time threefold with the same ...

Synthetic chemistry provides an essential material basis for our clothing, food, housing, transportation, and medicine and is an important driving force for economic development. However, traditional ...

The snapshots reveal key reactions steps. At 0 ms, water molecules occupy the substrate-binding site. At 50 ms, a substrate-cofactor intermediate forms. At 100 ms, the product is released, and the ...

Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are essential for life, as they play a crucial role in various biological processes, such as digestion, ...

Many enzymes require cofactors such as nicotinamide adenosine dinucleotide (NAD +) or nicotinamide adenosine dinucleotide phosphate (NADP +) to shuttle electrons between reactions. Artificial redox ...

(Nanowerk News) Reporting in Science ("De novo design of porphyrin-containing proteins as efficient and stereoselective catalysts"), researchers at UC Santa Barbara, UCSF and the University of ...

Schematic diagram of creating artificial enzyme-mimicking nanopockets in zirconium terephthalate UiO-66 for transfer hydrogenation of alkyl levulinates towards gamma-valerolactone. Credit: Tang ...

Enzymology is the study of enzymes and enzyme-catalyzed reactions. Enzymes are biological catalysts that accelerate the rate of biological reactions. They can also perform multiple reactions ...

A new study published in the journal Nature Catalysis on February 10, 2020, reports the creation of a new artificial enzyme from two components, both non-biological in origin. This event marks the ...

In living cells, enzymes drive biochemical metabolic processes. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as ...