Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an estrogen independent manner. Targeting vimentin and/or the long ...

Living cells are constantly exposed to a wide variety of mechanical stresses: heart and lungs must withstand expansion and contraction; our skin must be resistant to tearing whilst retaining ...

Just as the skeleton and muscles move the human body and hold its shape, the cells of the body are stabilized and moved by a cellular skeleton. This cellular skeleton is a dynamic structure, ...

We previously demonstrated that truncated desmoplakin I (DP I) molecules containing the carboxyl terminus specifically coalign with and disrupt both keratin and vimentin intermediate filament (IF) ...