Figure 1: Chemical structure of the peptidomimetic inhibitor BILC 821 of HCMV protease. The four unique molecules of HCMV protease in the crystal belong to two separate dimers. The four monomers, and ...
When a drug molecule binds to its target protein, it stays bound for some time before eventually unbinding the target. The actual time how long a drug molecule resides bound to its target varies among ...
The different morphologic subtypes of thyroid cancer correlate with specific genetic lesions (see Table 1). Two PROTEIN KINASES, namely, RET, a transmembrane receptor tyrosine kinase, and BRAF, a ...
BIRMINGHAM, Ala. - University of Alabama at Birmingham researchers have created a small molecule that prevents or impedes tooth cavities in a preclinical model. The inhibitor blocks the function of a ...
A multidisciplinary team of researchers have developed an anti-inflammatory drug molecule with a new mechanism of action. By inhibiting a certain protein, the researchers were able to reduce the ...
The field of small molecules has moved from multikinase inhibitors to the development of highly selective inhibitors. Modern pharmacology can overcome some of the limitations of first-generation ...
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