Nature

The myeloid-binding peptide adenoviral vector enables multi-organ vascular endothelial gene targeting

All mice were of C57BL/6J background and 7–14 weeks of age. Mice were obtained from Jackson Laboratory (Bar Harbor, ME, USA) or through breeding in authors’ animal facility. Experimental procedures ...
Nature

A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism

Specific and efficient gene delivery to the lung has been hampered by liver sequestration of adenovirus serotype 5 (Ad5) vectors. The complexity of Ad5 liver tropism has largely been unraveled, ...