Persistent inflammation may influence neurodegeneration through microglial activation, yet evidence remains hypothesis driven ...
Abnormal microglial energy metabolism in AD. Translocation of Aβ into microglial mitochondria by the outer membrane translocase (TOM) impairs mitochondrial function and inhibits phagocytosis. TREM2 ...
Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an ...
Researchers at University of Tsukuba have discovered that an immunosuppressive drug affects microglia, the resident immune ...
The idea that infiltrating T cells contribute to a neurodegenerative environment in aging and in Alzheimer’s disease has gotten another boost. In the June 27 Nature Neuroscience, scientists led by ...
TMEM97 regulates microglial activation and neuronal stress pathways linked to neuropathic pain and neuroinflammation in multiple sclerosis (MS). Pharmacological targeting of TMEM97 has shown ...
Alzheimer's disease (AD) is marked by severe neurodegeneration and cognitive decline, presenting significant challenges for its prevention and treatment. Traditional hypotheses have focused on amyloid ...
When microglia wind up with a belly full of lipid droplets, it’s a sign that the cells are rallying, perhaps in vain, to a neurodegenerative threat. But according to a study published July 10 in Cell ...
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