You might well think that myelin, the fatty insulation that speeds action potentials between neurons, falls solely under the purview of oligodendrocytes. After all, these specialized cells wrap ...

Despite decades of research, scientists still grapple with the question of why neuronal health is compromised in neurodegenerative diseases. For a long time, scientists believed that Alzheimer’s ...

In FIRE mice, the lack of microglia causes myelin overgrowth and eventual degeneration, indicating that microglia may contribute to age-related neurodegenerative diseases. The liquid world of fetal ...

How oligodendrocytes use fatty acid metabolism as an energy reserve to maintain axonal function and myelin stability when glucose is scarce, offering insights into neurodegenerative disease mechanisms ...

Persistent inflammation may influence neurodegeneration through microglial activation, yet evidence remains hypothesis driven ...

In tauopathies, scientists tend to focus on neuronal tau. They track its pathology and blame it for dysfunctional microglia. Now, researchers led by Celeste Karch at Washington University, St. Louis, ...

Myelin is an insulating sheath around axons—the processes connecting nerve cells—that is mostly composed of lipids and proteins. It enables rapid conduction of electrical signals and supports neuronal ...

Efficient removal of abnormal myelin allows survival of nerve fibers targeted by adaptive immune cells, according to a novel study. Myelin is an insulating sheath around axons -- the processes ...