Synaptic transmission is an energy hog. It requires neurons to tap ATP reserves to respond to incoming signals. How do they pull this off, thousands to millions of times per day? A new study ...

A research team has successfully demonstrated the world's first gene-editing treatment for Leber's hereditary optic ...

Senescence, a state in which cells neither divide nor die, but simply linger, has been linked to aging and neurodegeneration. What causes such cells to appear in old brains, and how might they wreak ...

Researchers have long believed that neurons rely on glucose nearly entirely for fuel. The brain’s enormous energy requirements were presumed to be supplied by sugar alone, in contrast to muscle or ...

A clearance mechanism involving microglia has been known to relieve neurons of toxic protein aggregates such as those associated with Alzheimer’s disease and Parkinson’s disease. Unfortunately, this ...

In Alzheimer’s disease and other dementias, a protein called tau can pile up inside brain cells and form toxic clumps. Those clumps help drive memory loss and other symptoms.

Ancient bacteria that have evolved to become integral to our cells – converting nutrients from food into energy – may also contribute to neurologic disorders, such as spinal muscular atrophy (SMA) and ...

Biological aging undeniably affects human cognitive function. 1 However, how this happens—the underlying factors, interactions, and processes—remains unclear. He and his team want to understand how ...

A new study from Karolinska Institutet shows that damage to small blood vessels in the hereditary disease CADASIL may disrupt ...