How cancer cells die from chemotherapy: a new pathway. We have been treating cancer by damaging the DNA of tumor cells for over a hundred years, for example with radiation and che ...

Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

Researchers have elucidated the role of the p53 gene in ulcerative colitis. The study suggests a potential new drug target to stop disease progression to cancer. Researchers in the lab of Michael ...

Apoptosis, or programmed cell death, is a tightly regulated biological process necessary for normal tissue maintenance and development. However, aberrations in apoptotic signaling networks are ...

Mitochondria are involved in apoptosis, necrosis, pyroptosis, and iron death. At present, the research on cell apoptosis is relatively thorough, and the mechanism of mitochondria in it has also been ...

Cancer begins when mutations in specific genes override the body’s built-in controls on cell division, allowing rogue cells ...