A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell clusters called tertiary lymphoid structures (TLSs) in response to foreign ...

How do tertiary lymphoid structures influence immunotherapy outcomes in Merkel cell carcinoma? Spatial proteomics reveals key ...

A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a ...

Tertiary lymphoid structures (TLS) are ectopic cellular hubs that coordinate immunity within patient tumors. TLS also correlate with improved prognosis and superior response to immunotherapy. While ...

Advances in cancer immunotherapy suggest that tumor-infiltrating lymphocytes (TILs) are critical for the elimination of tumor cells and maintenance of effective immunosurveillance. Spatial phenotyping ...

Please provide your email address to receive an email when new articles are posted on . A machine learning model may aid the detection and classification of tertiary lymphoid structures associated ...

Researchers have identified how to encourage tumors to build their own immune hubs that look and function like lymph nodes, ...

A team led by surgeon-scientist Dr. Vinod Balachandran identified the molecular pathway involved in the formation of tertiary lymphoid structures. Therapeutically targeting this pathway could ...

Gene modules in association with Kaiso and LC3 regulatory pathways to predict survival and response to therapy. This is an ASCO Meeting Abstract from the 2022 ASCO Annual Meeting I. This abstract does ...

Discover how specialized cells form immune-boosting niches in lung tumors, unlocking new strategies to enhance cancer treatments and improve outcomes. Study: Fibroblastic reticular cells generate ...