NFL picks, predictions, odds for Week 17
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The Minnesota Vikings ride into Week 17 with an injury report that is growing by the day, but at least they carry with them a three-game winning streak. The injuries are going to really be felt on Christmas Day when they deal with a Detroit Lions team that is playing with a chip on their shoulder.
Lions vs. Vikings is the middle game on Christmas, with Detroit having to avoid another loss to keep its season alive.
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Lions vs. Vikings prediction, odds, start time: 2025 Christmas Day NFL picks from advanced model
The latest Vikings vs. Lions odds have Detroit favored by 7 points, while the over/under for total points scored is 44.5 via DraftKings Sportsbook. Before making any Lions vs. Vikings picks, check out the NFL predictions from the SportsLine Projection Model .
The Detroit Lions committed six turnovers at the Minnesota Vikings to let a largely terrific defensive effort go to waste.