i-DNA 'peek-a-boo structures' form in living cells and regulate genes linked to cancer

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold ...

The surprising power of a tiny, disordered protein in a mitochondrial supercomplex

For decades, scientists assumed that order drives efficiency. Yet in the bustling machinery of mitochondria—the organelles ...
GitHub

Python rich client for visual protein Sequence to Structure Analysis (PySSA)

📣 Update details for version 1.3.0 📣 Please reinstall PySSA if your current version is 1.2.0 or older! Version 1.3.0 fixes the bug that every structure ...
News-Medical.Net

Unusual i-DNA structure shown to regulate genes and cancer

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions it can temporarily fold into unusual shapes.
GitHub

PLAID (Protein Latent Induced Diffusion)

PLAID is a multimodal generative model that can generate protein sequence and all-atom structure based on conditional function and taxonomic prompts. Please see our ...
IEEE

HighMPNN: A Graph Neural Network Approach for Structure-Constrained Cyclic Peptide Sequence Design

Abstract: Cyclic peptides become attractive therapeutic candidates due to their diverse biological activities. However, existing deep learning-based sequence design models, such as ProteinMPNN, are ...
IEEE

Protein-Binding RNA Prediction Based on Integrated Sequence-Structure-Function Pre-Training

Abstract: RNA binding proteins (RBPs) play a crucial role in regulating biological functions through their interactions with specific RNAs, significantly impacting various life processes.