DHT promotes SORT1 ubiquitination degradation, liberating ATG5 and ATG16L1 from the SORT1 complex. This process increases the expression of ATG5 and ATG16L1, leading to autophagosome accumulation ...
A recent study published in Engineering has shed light on the potential therapeutic effects of dihydrotanshinone I (DHT), a compound derived from the traditional Chinese herb Salvia miltiorrhiza, on ...
Engineered AAV vectors with dual tumor-specific promoters for safer and more effective cancer therapy. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not ...
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience. Fragmented investigation has ...
Novel camptothecin-peptide conjugates are well tolerated and associated with significant tumor regression in colorectal cancer and triple-negative breast cancer xenograft models SORT1 gene silencing ...
Focus on human epidermal growth factor receptor 2 (HER2) positive metastatic colorectal cancer (HER2+ mCRC): A real world retrospective analysis. This is an ASCO Meeting Abstract from the 2024 ASCO ...
The preclinical data presented at AACR add to the sizeable body of evidence supporting the potential utility of the SORT1+ Technology™ platform as an engine for the development of novel peptide-drug ...
MONTREAL, April 08, 2024 (GLOBE NEWSWIRE) -- Theratechnologies Inc. (“Theratechnologies” or the “Company”) (TSX: TH) (NASDAQ: THTX), a biopharmaceutical company focused on the development and ...
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