The new workflow was adapted from an enzymatic DNA tagging technology, DNA-TAG, previously developed in the Devaraj lab. In ...
Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...
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Spatial proteomics: Mapping protein organization across cells and tissues
Advancements in spatial proteomics enable detailed tissue mapping, linking protein localization to disease mechanisms and ...
Squamous cell carcinoma of the lung is linked to smoking and requires early detection and accurate staging for effective treatment. Diagnosis involves imaging and biopsy, with the TNM system used to ...
Immunology and Inflammation Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs Gagandeep Kaur ...
Scientists at Duke-NUS Medical School have developed two powerful computational tools that could transform how researchers study the "conversations" between cells inside the body. The tools, called ...
Spatial transcriptomics (ST) technologies reveal the spatial organization of gene expression in tissues, providing critical insights into development, neurobiology, and cancer. However, the high cost ...
Osimertinib Versus First-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Metastatic EGFR-Mutant Non–Small Cell Lung Cancer: A Target Trial Emulation Study of Real-World ...
Spatial ribonucleic acid (RNA) transcriptomics measures gene expression while preserving each molecule’s coordinates in intact tissue, tying transcripts to histology and local microenvironments.
T cell engagers, including Imdelltra, show promise in small cell lung cancer, outperforming chemotherapy in trials and changing the standard of care. Antibody-drug conjugates like I-DXd and ABBV-706 ...
Researchers uncovered a powerful weakness in lung cancer by shutting down a protein that helps tumors survive stress. When this protein, FSP1, was blocked, lung tumors in mice shrank dramatically, ...
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