Apr 11, 2019 · CD22 popped up in screening for suppressors of microglial phagocytosis. The receptor is upregulated in aging mice and in Alzheimer’s. Blocking CD22 improves phagocytosis and memory in …

Apr 26, 2022 · Wyss-Coray and colleagues previously reported that microglia in aged mice express CD22, which functions as an inhibitory receptor of phagocytosis (Pluvinage et al., 2019). Although …

Dec 8, 2021 · In human brain, CD22 is expressed in oligodendrocytes, its receptor on microglia. Binding of sCD22 to IGFR2 scrambles lysosomal trafficking, and lipids build up. Blocking this binding …

Dec 8, 2021 · The most compelling observation in this study is the demonstration that disruption of the CD22-IGF2R interaction ameliorates lysosome dysfunction in human NPC1-mutant iPSC-derived …

Moved Permanently The document has moved here.

Jun 23, 2004 · Triple-Colour Reagent, Anti-Human TdT/FITC Anti-Human CD22/RPE Anti-Human CD3/APC; simultaneous detection and enumeration of T and B-lymphocyte precursor cells, B cells …

Charbonneau H, Tonks NK, Walsh KA, Fischer EH. The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase. Proc Natl Acad Sci U S A. 1988 Oct;85 (19):7182-6. …

Don’t already have an account? Creating an account has many great benefits and features. Receive Notifications Find out when the topics & news articles you care about have new content. Save …

Dec 17, 2025 · Background Selnoflast is an inhibitor of inflammasomes containing NLRP3, or nod-like receptor family, pyrin domain-containing protein 3. Inflammasomes are multiprotein, cytosolic …

Luque M, Matic M, Heras-Garvin A, Amo-Aparicio J, Luk K, Haindl MT, Khalil M, Skouras DB, Dinarello CA, Stefanova N. Pharmacologic NLRP3 Inhibition Modulates Parkinson's Disease-Associated …