Protective Microglia Unmasked: They Act Like Regulatory T Cells
Nov 13, 2025 · PU.1-low microglia were rare, making up less than 1 percent of the total. To a “T.” A subtype of regulatory microglia express many of the immunomodulatory receptors typically found on …
Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Jan 17, 2025 · Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome. Previously, Young and colleagues found that while SORL1 …
Drivers for Common Microglial States Identified | ALZFORUM
Oct 22, 2025 · As readouts, they selected a marker for each of the most common microglial states: tetraspanin CD9 for DAM, interferon-induced protein IFIT1 for IRM, major histocompatibility complex …
ACE Supercharges Microglia to Shrink Plaques | ALZFORUM
Jul 3, 2025 · Mouse microglia got a genetic tune-up. On 9 June in Nature Aging, researchers led by Warren G. Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing …
Lipid-Laden, Sluggish Microglia? Blame Aβ. - ALZFORUM
Sep 6, 2023 · Microglia and macrophages make lipid droplets when stressed by inflammation. Scientists believe the lipids sustain the cells’ metabolic need, enabling them to respond to threats (van …
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease ...
Nov 1, 2024 · ApoE and Aβ Click in Lysosomes, Seeding Plaque Kaji et al. propose that fibrillar ApoE—likely forming in microglia lysosomes after internalization and delipidation of the lipid …
TREM2: A Chill Pill for Neurons? | ALZFORUM
Apr 17, 2025 · The microglia then use a cell-specific ATP/ADP hydrolyzing ectoenzyme called CD39 to convert the ATP into AMP, which is then hydrolyzed to adenosine via CD73 receptors expressed by …
Implicated in ARIA: Perivascular Macrophages and Microglia
Aug 16, 2024 · Others in Philadelphia focused on the mechanisms underlying ARIA. Inflammation is emerging as a key culprit, with microglia and perivascular macrophages both playing a role. The …
Paper Alert: APOE4 Packs on Lipid Droplets in Microglia
Mar 13, 2024 · Last year, scientists led by Tony Wyss-Coray, Stanford University, reported that Aβ induced formation of lipid droplets within human microglia, and attributed this to an uptick in a …
Microglia Build Plaques to Protect the Brain - ALZFORUM
Apr 22, 2021 · Could it be that microglia build plaques rather than bust them? In the April 15 Nature Immunology, researchers led by Greg Lemke at the Salk Institute for Biological Studies, La Jolla, …